11/7/2022 0 Comments Vitamin r review![]() ![]() The inclusion criteria were: (1) published observational retrospective and prospective studies, (2) Information on serum 25-OHD with a clear cut-off value ranging from 20 to 30 ng/mL, (3) comparing patients with COVID-19 vs non-COVID-19 OR severity in COVID-19 patients OR mortality in COVID-19 patients. This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guideline. This systematic review and meta-analysis aimed to assess whether low serum 25-OHD is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19. ![]() Numerous studies on vitamin D in COVID-19 patients also have conflicting results, similar to other diseases. Nevertheless, controversies exist, a study indicates that low serum 25-hydroxyvitamin D (25-OHD) was not associated with lung injury or mortality in severe sepsis and trauma ( 6). Vitamin D is known to modulate immune response ( 4) and its deficiency was associated with respiratory distress in patients hospitalized for pneumonia ( 5). Although most COVID-19 patients have mild-moderate symptom, a considerable number of patients, especially in patients with pre-existing comorbidities, experiences severe infection that might lead to death ( 2, 3). ![]() Meta-regression analysis showed that the association between low serum 25-OHD and mortality was affected by male gender (OR = 1.22, p = 0.002), diabetes (OR = 0.88, p = 0.019).Ĭonclusion: Low serum 25-OHD level was associated with COVID-19 infection, severe presentation, and mortality.Ĭoronavirus disease 2019 (COVID-19) is one of the most prevalent diseases to date ( 1). Low serum 25-OHD was associated with higher mortality (OR = 3.08, p = 0.011 I 2: 80.3%), with a sensitivity of 85%, specificity of 35%, PLR of 1.3, NLR of 0.44, and DOR of 3. Higher rate of severe COVID-19 was observed in patients with low serum 25-OHD (OR = 1.90, p = 0.003 I 2: 55.3%), with a sensitivity of 83%, specificity of 39%, PLR of 1.4, NLR of 0.43, and DOR of 3. Low serum 25-OHD was associated with higher rate of COVID-19 infection compared to the control group (OR = 2.71, p < 0.001 I 2: 92.6%). Results: There were 14 studies comprising of 999,179 participants. The secondary outcome was susceptibility and severe COVID-19. The main outcome was mortality defined as non-survivor/death. Other cut-off values were excluded to reduce heterogeneity. Low serum 25-OHD refers to participants with serum 25-OHD level below a cut-off point ranging from 20 to 30 ng/mL. We include published observational prospective and retrospective studies with information on 25-OHD that reported main/secondary outcome. Methods: Systematic literature searches of PubMed, Scopus, and Embase database up until 9 December 2020. Hasan Sadikin General Hospital, Bandung, Indonesiaīackground: This systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19. 3Department of Child Health, Faculty of Medicine, Universitas Padjadjaran/Dr.2Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.Hasan Sadikin General Hospital, Bandung, Indonesia 1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr.Mohammad Rizki Akbar 1 *, Arief Wibowo 1, Raymond Pranata 1,2 and Budi Setiabudiawan 3 ![]()
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